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This family contains only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, besides histone, quite a lot of non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and parts of the TATA binding protein (TBP) complicated, TBP-associated factors TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-K (goal lysine is bold), is also acknowledged by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the methyl mark on most of these substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a classic mannequin for dynamic lysine methylation of both histone and non-histone proteins.
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